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New immunological approaches in treating and diagnosing CNS diseases
Description:Systematic review protocol, Surgery, Trauma, Opioids, Risk factors, Prolonged therapy, Long-term use Introduction Opioid prescriptions have significantly increased over the last two to three decades, especially in the USA and across Canada [ 1 , 2 ]. This lack of knowledge most likely contributes to the unplanned development of prolonged opioid therapy. Due to the heterogeneity in the literature, it has been difficult to come to a specific conclusion. A key feature of this defense mechanism is its ability to differentiate between self and nonself. However, in autoimmune diseases, the host's immune system fails to discriminate self versus foreign. Opioids remain among the most widely used analgesic medications in the treatment of chronic non-cancer pain CNCP.
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