Central nervous system drug penetration
Drug delivery to the central nervous system: a review.
Chem Biodivers. Nov;6(11) doi: /cbdv Addressing central nervous system (CNS) penetration in drug discovery: basics and.
INTRODUCTION
Penetration of drugs through the blood-cerebrospinal fluid/blood-brain barrier for treatment of central nervous system infections. Nau R(1), Sörgel F, Eiffert H.
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Description:By BioFocus December 07, Problem: Penetration of a drug into the central nervous system CNS is vital for pharmacological efficacy if the target is located in the CNS, but represents an unwanted risk factor if the therapeutic target is peripherally located. CNS penetration is therefore required when it is known that the peripheral target exists in the CNS, or when and if any interactions with targets located or co-located in the CNS are likely to have undesirable consequences. A commonly quoted index of brain penetration is the ratio of drug in brain tissue to that in circulation, i.
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